Polymorphism p53 codon-72 and invasive cervical cancer: a meta-analysis.

Jee, S H; Won, S Y; Yun, J E; Lee, J E; Park, J S; Ji, S S
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2004Jun ; 85 ( 3 ) :301-8.
저자 상세정보
Jee, S H -
Won, S Y -
Yun, J E -
Lee, J E -
Park, J S -
Ji, S S -
OBJECTIVES: Although some studies have reported that the arginine isoform on codon 72 of p53 increases the susceptibility to invasive cervical cancer, such data remain controversial. The objective of this study was to quantitatively summarize the evidence for such a relationship.

METHODS: Our data sources consisted of a MEDLINE search of the literature published before December 2002, bibliography review, and expert consultation. Thirty-seven studies met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, and method of genotype determination was abstracted by two reviewers using a standardized protocol. The overall odds ratio (OR) of the p53 gene on invasive cervical cancer was estimated using the Mantel-Haenzel method.

RESULTS: The overall OR (95% confidence interval) for cervical cancer among those with the homozygous mutant (Arg/Arg) was 1.2 (1.1-1.3, P=0.001) compared with those with the heterozygous mutant (Arg/Pro). By a cellular type of cervical cancer, the overall OR among those with Arg/Arg was statistically significant in adenocarcinomas (1.7, 1.1-2.6, P=0.024), but not in squamous cell carcinomas (1.1, 0.9-1.2, P=0.960), compared with Pro/Pro. Compared with Arg/Pro, the OR among those with Arg/Arg was statistically significant in HPV types 16 (1,5, 1.2-2.0, P=0.002).

CONCLUSIONS: Overall, the p53 gene was associated with increased risk for invasive cervical cancer. However, the risk varied by country, cellular, and HPV type.
Polymorphism, Codon 72 of p53, Cervical cancer
Adenocarcinoma/*genetics, Carcinoma, Squamous Cell/*genetics, Case-Control Studies, Codon, Female, Genetic Predisposition to Disease, Humans, Odds Ratio, Polymorphism, Genetic, Seroepidemiologic Studies, Tumor Suppressor Protein p53/*genetics, Uterine Cervical Neoplasms/epidemiology/*genetics

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
individuals homozygous for the arginine variant of codon 72 of the p53 gene in itself are at a modestly increased risk for contracting cervical cancer.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03