Lee, Jeong Min; Jin, Gong Yong; Goldberg, S Nahum; Lee, Yong Cheol; Chung, Gyung Ho; Han, Young Min; Lee, Sang Yong; Kim, Chong Soo
Radiology
2004Jan ; 230 ( 1 ) :125-34.
PMID : 14645875
ÀúÀÚ »ó¼¼Á¤º¸
Lee, Jeong Min -
Jin, Gong Yong -
Goldberg, S Nahum -
Lee, Yong Cheol -
Chung, Gyung Ho -
Han, Young Min -
Lee, Sang Yong -
Kim, Chong Soo -
ABSTRACT
PURPOSE: To assess technical feasibility, efficacy, and complications of percutaneous computed tomography (CT)-guided transthoracic radiofrequency (RF) ablation for treating inoperable non-small cell lung cancer (NSCLC) and lung metastases. MATERIALS AND
METHODS: Twenty-six patients with 27 NSCLCs and four patients with five lung metastases underwent RF ablation with cooled-tip electrodes with CT guidance. Patients were not candidates for surgery because of either advanced-stage disease (n = 20) and/or comorbid processes (n = 4) or refusal to undergo surgery (n = 6). The procedure was performed with the intent to cure in 10 (33%) patients with stage I tumors and as palliative therapy in 20 (67%) patients. Contrast material-enhanced CT was performed immediately, 1 month, and then every 3 months after RF ablation to evaluate the response to therapy. Time to death for each patient was calculated with Kaplan-Meier analysis, and the effect of tumor size and the extent of coagulation necrosis on time to death were determined.
RESULTS: Complete necrosis was attained in 12 (38%) of 32 lesions; partial (>50%) necrosis, in the remaining 20 (62%) lesions. Tumor size was a major discriminator in achieving complete necrosis. Complete necrosis was attained in all six (100%) tumors smaller than 3 cm but only in six (23%) of 26 larger tumors (P <.05). Mean survival of patients with complete necrosis (19.7 months) was significantly better than that of patients with partial necrosis (8.7 months) (P <.01). There were three (in 30 patients, 10%) major complications, which included acute respiratory distress syndrome, and two pneumothoraces that required thoracostomy. CONCLUSION: RF ablation appears to be a safe and promising procedure for the treatment of inoperable NSCLC and metastases. CI - Copyright RSNA, 2004
Adult, Aged, Carcinoma, Non-Small-Cell Lung/mortality/secondary/*surgery, *Catheter Ablation/adverse effects, Feasibility Studies, Female, Follow-Up Studies, Humans, Lung Neoplasms/mortality/pathology/*surgery, Male, Middle Aged, Survival Rate
MESH
Adult, Aged, Carcinoma, Non-Small-Cell Lung/mortality/secondary/*surgery, *Catheter Ablation/adverse effects, Feasibility Studies, Female, Follow-Up Studies, Humans, Lung Neoplasms/mortality/pathology/*surgery, Male, Middle Aged, Survival Rate
¸µÅ©