KCTBASE

Hyperlipidemia and erectile dysfunction.

Kim, S C

Asian journal of andrology
2000Sep ; 2 ( 3 ) :161-6.

PMID : 11225973

저자 상세정보

Kim, S C - Department of Urology, College of Medicine, Chung-Ang University, Seoul, Korea. saeckim@unitel.co.kr

ABSTRACT

We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and relaxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyperlipidemia in impotent patients; 2) erection response to intracavernous injection of papaverine in impotent patients with hyperlipidemia; 3) relaxation responses of isolated cavernosal smooth muscles to endothelium-independent and endothelium-dependent vasodilators in impotent patients with hypercholesterolemia or hypertriglyceridemia; 4) involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits; 5) effects of isolated lipoproteins and triglyceride, combined oxidized LDL plus triglyceride, and combined oxidized LDL plus HDL on contractile and relaxation response of rabbit cavernous smooth muscles; 6) involvement of e-NOS in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit. Hypercholesterolemia may cause impairment of endothelium-dependent relaxation. Oxidized LDL is the major causative cholesterol of the impaired relaxation response. A chain reaction, the production of superoxide radicals and functional impairment of eNOS may be a major cause of the functional impairment in the early stages of hypercholesterolemia.

hypercholesterolemia; hypertriglyceridemia; LDL lipoproteins; HDL lipoproteins; superoxide radicals; NO synthase; cavernous smooth muscle; erectile dysfunction

MESH

Animals, Erectile Dysfunction/*etiology, Humans, Hyperlipidemias/*complications/epidemiology/metabolism, Incidence, Male, Muscle Relaxation/physiology, Muscle, Smooth/physiology, Rabbits

링크

PubMed

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

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유효성결과(Recomendation)

The particulate cNOS activity was significantly (P<0.05) decreased in the experimental groups, while the cytosolic cNOS activity in the experimental groups was not different from the control group; Hypercholesterolemia may cause impairment of endothelium-dependent relaxation.

연구비지원(Fund Source)

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대표저자

DOI

KCD코드

ICD 03

건강보험코드