Kwon, H C; Kim, S K; Chung, W K; Cho, M J; Kim, J S; Kim, J S; Moon, S R; Park, W Y; Ahn, S J; Oh, Y K; Yun, H G; Na, B S
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
2000Aug ; 56 ( 2 ) :175-9.
PMID : 10927136
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Kwon, H C -
Kim, S K -
Chung, W K -
Cho, M J -
Kim, J S -
Kim, J S -
Moon, S R -
Park, W Y -
Ahn, S J -
Oh, Y K -
Yun, H G -
Na, B S -
ABSTRACT
PURPOSES: The objectives of this prospective clinical trial were to determine whether pentoxifylline improves the radiation response and survival in patients with non-small cell lung cancer. MATERIALS AND
METHODS: From July 1993 through October 1994, 64 patients with histologically confirmed Stage I, II and III non-small cell lung cancer were randomly divided into pentoxifylline (Pento)+Radiotherapy (RT) group and RT alone group. Out of the 64 patients, only 47 patients who had measurable tumors on chest X-ray views were analyzed and divided into Pento+RT group (n=27) and RT alone group (n=20). Total tumor dose of 65-70 Gy was delivered as conventional fractionated radiation schedules. Pento was given to the patients 3 x 400 mg/day with a daily dose of 1200 mg during RT.
RESULTS: Complete response (CR), partial response (PR), and stable in Pento+RT group were three (11%), 13 (48%), and 11 (41%), respectively, as compared with corresponding values of three (15%), 13 (65%), and four (20%) in the RT alone group. The median time to relapse in the Pento+RT group was 11 months which was 2 months longer than for the RT alone group (P>0.05). All the patients in both groups showed lower than or equal to grade 2 dysphagia, odynophagia, pulmonary fibrosis, and pneumonitis. The median survival was 18 months in the Pento+RT group and 7 months in the RT alone group. The 1-year survival rate was 60% in the Pento+RT group and 35% in the RT alone group, the 2-year survival rate was 18% in the Pento+RT group and 12% in the RT alone group. But these differences were not statistically significant (P>0.05). CONCLUSION: We concluded that Pento is a modestly effective radiation response modifier and provide benefit in the treatment of non-small cell lung cancer.
PentoxifyllineRadiotherapyNon-small cell lung cancerRadiation response modifier
MESH
Aged, Carcinoma, Non-Small-Cell Lung/*drug therapy/mortality/*radiotherapy, Dose Fractionation, Female, Follow-Up Studies, Humans, Lung Neoplasms/*drug therapy/mortality/*radiotherapy, Male, Middle Aged, Pentoxifylline/*administration & dosage, Probability, Prospective Studies, Radiation-Protective Agents/*administration & dosage, Radiotherapy/*methods, Radiotherapy, Adjuvant, Survival Analysis, Treatment Outcome
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