The prognostic impact of lymphocyte subsets in newly diagnosed acute myeloid leukemia
Blood Research 2018³â 53±Ç 3È£ p.198 ~ p.204
¹ÚÀ¯¹Ì(Park Yu-Mi) - Chungnam National University Hospital Department of Laboratory Medicine
ÀÓÁø¼÷(Lim Jin-Sook) - Chungnam National University Hospital Department of Laboratory Medicine
±è¼±¿µ(Kim Seon-Young) - Chungnam National University Hospital Department of Laboratory Medicine
¼ÛÀÍÂù(Song Ik-Chan) - Chungnam National University Hospital Department of Hemato-Oncology
±Ç°èö(Kwon Kye-Chul) - Chungnam National University Hospital Department of Laboratory Medicine
±¸¼±È¸(Koo Sun-Hoe) - Chungnam National University Hospital Department of Laboratory Medicine
±èÁö¸í(Kim Ji-Myung) - Chungnam National University Hospital Department of Laboratory Medicine
Abstract
Background: Tumor-infiltrating lymphocytes, which form a part of the host immune system, affect the development and progression of cancer. This study investigated whether subsets of lymphocytes reflecting host-tumor immunologic interactions are related to the prognosis of patients with acute myeloid leukemia (AML).
Methods: Lymphocyte subsets in the peripheral blood of 88 patients who were newly diagnosed with AML were analyzed by quantitative flow cytometry. The relationships of lymphocyte subsets with AML subtypes, genetic risk, and clinical courses were analyzed.
Results: The percentages of T and NK cells differed between patients with acute promyelocytic leukemia (APL) and those with AML with myelodysplasia-related changes. In non-APL, a high proportion of NK cells (>16.6%) was associated with a higher rate of death before remission (P=0.0438), whereas a low proportion of NK cells (¡Â9.4%) was associated with higher rates of adverse genetic abnormalities (P=0.0244) and relapse (P=0.0567). A multivariate analysis showed that the lymphocyte subsets were not independent predictors of survival.
Conclusion: Lymphocyte subsets at diagnosis differ between patients with different specific subtypes of AML. A low proportion of NK cells is associated with adverse genetic abnormalities, whereas a high proportion is related to death before remission. However, the proportion of NK cells may not show independent correlations with survival.
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Acute myeloid leukemia, Lymphocyte subset, NK cells, Prognosis
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À¯È¿¼º°á°ú(Recomendation)
The proportions of lymphocyte subsets, including the NK cell subset, do not show independent correlations with clinical survival.