Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis
Psychiatry Investigation 2018³â 15±Ç 7È£ p.701 ~ p.709
ȲÀÎö(Hwang In-Cheol) - Gachon University College of Medicine Gil Medical Center Department of Family Medicine
³ª°æ¼¼(Na Kyoung-Sae) - Gachon University College of Medicine Gil Medical Center Department of Psychiatry
ÀÌÀ¯Áø(Lee Yu-Jin) - Seoul National University College of Medicine Department of Psychiatry
°½Â°É(Kang Seung-Gul) - Gachon University College of Medicine Gil Medical Center Department of Psychiatry
Abstract
Objective: This study investigated the proposed association between restless legs syndrome (RLS) and the prevalence of hypertension.
Methods: A meta-analysis was conducted based on searches of the PUBMED, EMBASE, Cochrane Library, and Korean electronic databases. Cohort and cross-sectional studies reporting the incidence of hypertension in individuals with RLS were included. Dichotomous data were pooled to obtain an odds ratio (OR) and 95% confidence interval (CI) for the prevalence of hypertension in individuals with RLS. The main outcome measure of the study was prevalence of hypertension in patients with RLS compared with a control group.
Results: One cohort study and eight cross-sectional studies were included in the meta-analysis. Individuals with RLS had an increased prevalence of hypertension (all studies: OR=1.13, 95% CI=1.04-1.23; cross-sectional studies: OR=1.12, 95% CI=1.01-1.24). However, in subgroup analyses controlling for cardiovascular risk factors, such as diabetes mellitus and dyslipidemia, the differences in the prevalence of hypertension between RLS and control patients were no longer significant.
Conclusion: Patients with RLS may have a higher prevalence of hypertension, according to a pooled analysis, but the results remain to be confirmed in well-designed prospective studies.
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Restless legs syndrome, Hypertension, Prevalence, Meta-analysis
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À¯È¿¼º°á°ú(Recomendation)
Inndividuals with RLS show a higher prevalence of hypertension, but well-designed, prospective studies are needed to confirm this finding.