¹é¼±ÇÏ(Baek Seon-Ha) - Hallym University Dongtan Sacred Heart Hospital Department of Internal Medicine
¹ÚÁø¾Æ(Park Jin-A) -
¹Ú¼¼ÈÆ(Park Se-Hoon) -
À¯¹Ì¿¬(Yu Mi-Yeon) -
½Åµ¿Ãµ(Shin Dong-Chun) -
¹Ú»óÇö(Park Sang-Hyun) -
ÇÑ°æµµ(Han Kyung-Do) -
±è¿ëö(Kim Yong-Chul) - Seoul National University Hospital Department of Internal Medicine
±èµ¿±â(Kim Dong-Ki) - Seoul National University Hospital Department of Internal Medicine
Áֱǿí(Joo Kwon-Wook) - Seoul National University Hospital Department of Internal Medicine
±è¿¬¼ö(Kim Yon-Su) -
ÀÌÇÏÁ¤(Lee Ha-Jeong) - Seoul National University Hospital Department of Internal Medicine
Abstract
Background : Recent studies have shown that patients with end-stage renal disease (ESRD) are at elevated risk of dementia. However, whether kidney transplantation (KT) lowers the risk for incident dementia remains unclear.
Methods : From the Korean National Health Insurance Service database, we identified incident KT recipients aged ¡Ã40 years without any history of dementia between 2007 and 2015. We also established a pair of age-, sex-, and inclusion year-matched control cohorts of patients with incident dialysis-dependent ESRD and members of the general population (GP) without a history of dementia, respectively. Cases of incident all-cause dementia, including Alzheimer disease (AD), vascular dementia (VD), and other kinds of dementia, were obtained from baseline until December 31, 2017.
Results : We followed 8,841 KT recipients, dialysis-dependent ESRD patients, and GP individuals for 48,371, 28,649, and 49,149 patient-years, respectively. Their mean age was 52.5 years, and 60.6% were male. Over the observation period, 55/43/19 KT recipients, 230/188/75 dialysis-dependent ESRD patients, and 38/32/14 GP individuals developed all-cause dementia/AD/VD. The risks of incident all-cause dementia, AD, and VD in KT recipients were similar to those in GP (hazard ratio: 0.74 [p = 0.20], 0.74 [p = 0.24], and 0.59 [p = 0.18], respectively) and significantly lower than those in dialysis-dependent ESRD patients (hazard ratio: 0.17 [p < 0.001], 0.16 [p < 0.001], and 0.16 [p < 0.001], respectively). Older age and diabetes mellitus at the time of KT were risk factors for incident all-cause dementia and AD in KT recipients.
Conclusion : This is the first study to show a beneficial impact of KT on incident dementia compared to dialysis dependency.
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Dementia, End-stage renal disease, General population, Kidney transplantation, Risk factors
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À¯È¿¼º°á°ú(Recomendation)
this epidemiologic study provides evidence that the risks of incident all-cause dementia, Alzheimer disease, and vascular dementia in KT recipients are significantly lower than those of dialysis-dependent ESRD patients.