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Serum Biomarkers for Cardiovascular Disease and Atrial Fibrillation in Ischemic Stroke: A Systematic Review and Meta-Analysis
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¿ì¸í¼ö(Woo Myoung-Soo) - Jeonju Kijeon College Department of Biomedical Laboratory Science
¹®¼Ò¶ó(Mun So-Ra) - Eulji University College of Health Science Department of Biomedical Laboratory Sciences
ÀÌÁö¿µ(Lee Ji-Yeong) - Eulji University College of Health Science Department of Biomedical Laboratory Sciences
Abstract
ÇãÇ÷¼º ³úÁ¹ÁßÀº ³úµ¿¸ÆÀÇ Ç÷ÀüÀ̳ª »öÀü¿¡ ÀÇÇØ Æó»öµÇ¾î»ê¼Ò°¡ Æ÷ÇÔµÈ Ç÷¾×ÀÌ ³ú¿¡ µµ´ÞÇÏ´Â °ÍÀ» ¹æÁöÇÏ°í, ½Å°æ ¼¼Æ÷ÀÇ ±«»ç¸¦ À¯¹ßÇÏ´Â °ÍÀÌ´Ù. º» ¿¬±¸ÀÇ ¸ñÀûÀº Áö±Ý±îÁö ¿¬±¸µÈ ÇãÇ÷¼º ³úÁ¹ÁßÀÇ Á¶±â Áø´ÜÀ» °¡´ÉÇÏ°Ô ÇÏ´Â ½ÉÇ÷°ü Áúȯ ¹× ½É¹æ¼¼µ¿ Áúȯ°ú °ü·ÃµÈ Ç÷û Èĺ¸ ¸¶Ä¿¸¦ Á¤¸®ÇÏ°í, °¢ ¸¶Ä¿ÀÇ ORÀ» ºñ±³ ºÐ¼®ÇÏ´Â °ÍÀÌ´Ù. º» ¿¬±¸¿¡¼´Â ¸ÞŸºÐ¼® ±â¹ýÀ» ÀÌ¿ëÇÏ¿© Ç÷û Èĺ¸ ¸¶Ä¿ÀÇ È¿°ú Å©±â¸¦ ºÐ¼®ÇÏ°íÀÚ ÇÏ¿´´Ù. ¡®½ÉÇ÷°üÁúȯ¡¯, ¡®½É¹æ¼¼µ¿¡¯, ¡®ÇãÇ÷¼º ³úÁ¹Áß¡¯, ¡®Ç÷û Ç¥ÁöÀÚ¡¯¸¦ Å°¿öµå·Î Æ÷ÇÔÇÏ´Â ³í¹®¿¡ ´ëÇÑ Çмú Database °Ë»ö¿¡¼ ÃßÃâµÈ µ¥ÀÌÅÍ´Â ¸ðµÎ ÇãÇ÷¼º ³úÁ¹Áß È¯ÀÚ¿¡ ´ëÇÑ °á°ú·Î Á¦ÇÑÇÏ¿´´Ù. ÀÌ ¿¬±¸¿¡¼ °¡Àå ¸¹ÀÌ °Ë»öµÈ ¸¶Ä¿´Â NT-proBNP, D-dimer, CRP ¹× GFAP µîÀ¸·Î ³ªÅ¸³µ´Ù. °á·ÐÀûÀ¸·Î, NT-proBNP´Â ÇãÇ÷¼º ³úÁ¹ÁßÀÇ Á¶±â Áø´Ü¿¡ ¸Å¿ì À¯¿ëÇÑ °ÍÀ¸·Î º¸À̸ç, ƯÈ÷ ½É¹æ¼¼µ¿(AF)ÀÇ Ç¥ÁöÀÚ·Î ¾Ë·ÁÁ® ÀÖÀ¸¸ç, ¾ÕÀ¸·Î ´õ ¸¹Àº ½É¹æ¼¼µ¿ Ç¥ÁöÀÚ°¡ ¹ß±¼µÇ¾î ¿¬±¸µÇ¾î¾ß ÇÒ °ÍÀÌ´Ù.
Ischemic stroke is caused by an occlusion by a thrombus or embolus in a cerebral artery, preventing oxygenated blood from reaching the brain and causing the necrosis of nerve cells. This paper summarizes the serum candidate markers associated with cardiovascular disease and atrial fibrillation (AF) disease that enable an early diagnosis of ischemic stroke studied thus far and compares the odds ratio (OR) of each marker. This study examined the effect size of these serum candidate markers using meta-analysis techniques. The academic database search screening for articles containing the keywords ¡°cardiovascular disease,¡± ¡°atrial fibrillation,¡± ¡°ischemic stroke,¡± and ¡°serum marker¡± was limited to results for patients with ischemic stroke. The most derived markers in this study were N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), D-dimer, C-reactive protein (CRP), and glial fibrillary acidic protein (GFAP), the rest being investigated individually. In conclusion, NT-pro-BNP appears to be very useful for the early diagnosis of ischemic stroke. Primarily, it is a marker of AF, and more AF markers will be uncovered and studied in the future.
Å°¿öµå
Atrial fibrillation, Biomarkers, Cardiovascular disease, Ischemic stroke
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À¯È¿¼º°á°ú(Recomendation)
ÇãÇ÷¼º ³úÁ¹Áß Á¶±â Áø´Ü¿¡ ½É¹æ¼¼µ¿ ¸¶Ä¿·Î ¾Ë ·ÁÁ®ÀÖ´Â NT-proBNP°¡ ¸Å¿ì À¯¿ëÇÒ °ÍÀ̹ǷΠÃßÈÄ ´õ ¸¹Àº ½É¹æ ¼¼µ¿ ¸¶Ä¿¸¦ ¹ß±¼ ¿¬±¸¸¦ ÇÏ¿© ÇãÇ÷¼º ³úÁ¹Áß Á¶±â Áø´Ü¿¡ Âü°íÇÏ´Â °ÍÀ» Á¦¾ÈÇÔ´Ù.