(Blanco Carlota) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
(Linares Antonio) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
(Dopico Jose) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
(Pico Alex) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
(Sobrino Tomas) - Health Research Institute of Santiago de Compostela Clinical Neurosciences Research Laboratory
(Leira Yago) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
(Blanco Juan) - University of Santiago de Compostela Faculty of Odontology Periodontology Unit
Abstract
Purpose: The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis.
Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed.
Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8¡¿103/¥ìL; 95% CI, 1.6, 4.0¡¿103/¥ìL; P<0.001) and IL-10 (estimated adjusted mean difference, ?10.4 pg/mL; 95% CI, ?15.8, ?5.0 pg/mL; P<0.001). The peri-implant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001).
Conclusions: Otherwise healthy individuals with peri-implantitis showed increased low-grade systemic inflammation and dyslipidemia.
Å°¿öµå
Cardiovascular diseases, Dyslipidemias, Inflammation, Leukocytes, Peri-implantitis
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
It can be concluded that otherwise healthy patients diagnosed with peri-implantitis presented with a low-grade inflammatory state (increased circulating levels of WBC) accompanied by dyslipidemia (increased blood levels of cholesterol and LDL).