±èÀ¯¸²(Kim You-Lim) - Konkuk University School of Medicine Konkuk University Hospital Department of Internal Medicine
¾ÈÅÂÁØ(An Tai-Joon) - Catholic University College of Medicine Yeouido St. Mary¡¯s Hospital Department of Internal Medicine
¹Ú¿ë¹ü(Park Yong-Bum) - Hallym University Kangdong Sacred Heart Hospital Department of Internal Medicine
±è°æÁÖ(Kim Kyung-Joo) - Catholic University College of Medicine Seoul St. Mary¡¯s Hospital Department of Internal Medicine
Á¶µµ¿¬(Cho Do-Yeon) - Health Insurance Review and Assessment Service Big Data Research Division
ÀÌÁø±¹(Rhee Chin-Kook) - Catholic University College of Medicine Seoul St. Mary¡¯s Hospital Department of Internal Medicine
À¯±¤ÇÏ(Yoo Kwang-Ha) - Konkuk University School of Medicine Konkuk University Hospital Department of Internal Medicine
Abstract
Background: The effect of underlying chronic obstructive pulmonary disease (COPD) on coronavirus disease 2019 (COVID-19) during a pandemic is controversial. The purpose of this study was to examine the prognosis of COVID-19 according to the underlying COPD.
Methods: COVID-19 patients were assessed using nationwide health insurance data. Comorbidities were evaluated using the modified Charlson Comorbidity Index (mCCI) which excluded COPD from conventional CCI scores. Baseline characteristics were assessed. Univariable and multiple logistic and linear regression analyses were performed to determine effects of variables on clinical outcomes. Ages, sex, mCCI, socioeconomic status, and underlying COPD were selected as variables.
Results: COPD patients showed older age (71.3¡¾11.6 years vs. 47.7¡¾19.1 years, p<0.001), higher mCCI (2.6¡¾1.9 vs. 0.8¡¾1.3, p<0.001), and higher mortality (22.9% vs. 3.2%, p<0.001) than non-COPD patients. The intensive care unit admission rate and hospital length of stay were not significantly different between the two groups. All variables were associated with mortality in univariate analysis. However, underlying COPD was not associated with mortality unlike other variables in the adjusted analysis. Older age (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.11-1.14; p<0.001), male sex (OR, 2.29; 95% CI, 1.67-3.12; p<0.001), higher mCCI (OR, 1.30; 95% CI, 1.20-1.41; p<0.001), and medical aid insurance (OR, 1.55; 95% CI, 1.03-2.32; p=0.035) were associated with mortality.
Conclusion: Underlying COPD is not associated with a poor prognosis of COVID-19.
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COVID-19, Chronic Obstructive Pulmonary Disease, Prognosis
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The intensive care unit admission rate and hospital length of stay were not significantly different between the two groups. All variables were associated with mortality in univariate analysis. However, underlying COPD was not associated with mortality unlike other variables in the adjusted analysis.