간암 국가암검진사업에 참여한 만성B형간염 환자에서 간암 발생률 조사
Incidence of Primary Liver Cancer in Subjects with Chronic Hepatitis B in Korean National Liver Cancer Screening Program

Journal of Liver Cancer 2017년 17권 2호 p.136 ~ p.143

최인승(Choi In-Seung) - 경희대학교 의학전문대학원 내과학교실
오치혁(Oh Chi-Hyuk) - 경희대학교 의학전문대학원 내과학교실
박소영(Park So-Young) - 경희대학교 의학전문대학원 내과학교실
안성은(Ahn Sung-Eun) - 경희대학교 의학전문대학원 영상의학교실
박성진(Park Seong-Jin) - 경희대학교 의학전문대학원 영상의학교실
최현림(Choi Hyun-Rim) - 경희대학교 의학전문대학원 직업환경의학과교실
김병호(Kim Byung-Ho) - 경희대학교 의학전문대학원 내과학교실
심재준(Shin Jae-Jun) - 경희대학교 의학전문대학원 내과학교실

Abstract

Background/Aims: To optimize efficacy of National Liver Cancer Screening Program (NLCSP) for subjects with chronic hepatitis B (CHB), it is needed to know the incidence of liver cancer and its predisposing factors in the program.

Methods: From January 2010 to December 2014, all the hepatitis B surface antigen (HBsAg) positive participants who received at least two or more abdominal ultrasonography under NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of primary liver cancer was calculated and related clinical factors were investigated.

Results: During 5 years, 541 subjects were enrolled. Mean age was 53 years old and 292 subjects (54%) were receiving antiviral agents. Liver cirrhosis (LC) was diagnosed in 212 (39.2%). Mean follow-up time was 2.36 years and 15 hepatocellular carcinoma and 1 intrahepatic cholangiocarcinoma were diagnosed. Annual incidence of primary liver cancer was 9.8 per 1,000 patient year. Cumulative incidence at 1, 3, and 5 year was 0.6%, 2.6%, and 6.4%, respectively. In multivariate analyses, LC (hazard ratio [HR] 8.74, 95% confidence interval [CI] 1.97?38.71, P=0.024), age (HR 1.08, 95% CI 1.01?1.15, P=0.024) were significantly associated with cancer development.

Conclusions: Despite of high rate of oral antiviral therapy, incidence of primary liver cancer is not low in CHB patients in Korea. Old age and presence of LC are independently associated with higher risk of cancer development during surveillance. This study could be used as baseline data for quality control of NLCSP.

키워드

Hepatocellular carcinoma, Hepatitis B, Chronic, Mass screening
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Old age and presence of LC are independently associated with higher risk of cancer development.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드