Genetic relationship between an endothelin 1 gene polymorphism and lead-related high blood pressure
Molecular & Cellular Toxicology 2016³â 12±Ç 2È£ p.111 ~ p.116
ÀÌÈ¿µ(Lee Hwa-Young) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
±èÇü±â(Kim Hyung-Ki) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
¿øÇѼÖ(Won Han-Sol) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
ÀÓÁöÀ±(Im Ji-Yun) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
±ÇÁØÅÃ(Kwon Jun-Tack) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
±èÇÐÀç(Kim Hak-Jae) - Soonchunhyang University College of Medicine Department of Clinical Pharmacology
Abstract
This study investigated the effect of an endothelin 1 (EDN1) T-1370G polymorphism on blood lead levels and lead-related blood pressure (LBP) of male Korean workers who had exposure to lead. A cross sectional study involving 771 male lead-exposed workers from Korea was conducted. High resolution melting analysis was used to differentiate the genotypes of the polymorphism. Association of clinical characteristics with genotypes as modifiers was estimated after adjusting for age, smoking status, drinking status, and job duration. Genotype and allele frequencies of the polymorphism were found to be associated with LBP. Blood lead levels were not associated with genotype or allele frequencies. Based on these results, it was concluded that G allele carrier (GG or GG+TG) and G allele of EDN1 polymorphism might be a risk factor of lead-related high blood pressure.
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Endothelin 1, Lead, Blood pressure, Polymorphism
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Genotype and allele frequencies of the polymorphism were found to be associated with LBP.