대장암 환자의 옥살리플라틴(oxaliplatin) 유도 말초신경병증에 대한 약물유전학적 접근: 체계적 문헌고찰
Current Pharmacogenetic Approach for Oxaliplatin-induced Peripheral Neuropathy among Patients with Colorectal Cancer: A Systematic Review

Journal of Korean Biological Nursing Science 2018년 20권 2호 p.55 ~ p.66

안수정(Ahn Soo-Jung) - 연세대학교 대학원
최소영(Choi So-Young) - 연세대학교 대학원
정혜정(Jung Hye-Jeong) - 세브란스병원
추상희(Chu Sang-Hui) - 연세대학교 간호대학

Abstract

Purpose: Peripheral neuropathy is common among colorectal cancer (CRC) patients who undergo oxaliplatin-based (OXL) chemo- therapy. A pharmacogenetic approach can be used to identify patients at high-risk of developing severe neuropathy. This type of ap- proach can also help clinicians determine the best treatment option and prevent severe neurotoxicity. The purpose of this study is to investigate the evidence of pharmacogenetic markers for OXL-induced peripheral neuropathy (OXIPN) in patients with CRC.

Methods: A systematic literature search was conducted using the following databases up to December 2017: Pubmed, EMBASE, and CI- NAHL. We reviewed the genetic risk factors for OXIPN in observational studies and randomized controlled clinical trials (RCTs). All pro- cesses were performed independently by two reviewers.

Results: Sixteen studies published in English between 2006 and 2017 were included in this review. A genome-wide association approach was used in one study and various candidate genes were tested, based on their functions (e.g., DNA damage or repair, ion channels, anti-oxidants, and nerve growth etc.). The genes associated with inci- dence or severity of OXIPN were ABCG2, GSTP1, XRCC1, TAC1, and ERCC1.

Conclusion: This study highlighted the need and the im- portance of conducting pharmacogenetic studies to generate evidence of personalized OXIPN symptoms management. Additional studies are warranted to accelerate the tailored interventions used for OXIPN in patients with CRC (NRF-2014R1A1A3054386).

키워드

옥살리플라틴, 말초신경병증, 약물유전학, 대장암
Oxaliplatin, Peripheralneuropathy, Pharmacogenetics, Colorectalcancer
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) KoreaMed 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
This study highlighted the need and the importance of conducting pharmacogenetic studies to generate evidence of personalized OXIPN symptoms management.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드