Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment
BMB Reports 2020³â 53±Ç 8È£ p.400 ~ p.412
(Jayaramayya Kaavya) - Bharathiar University Department of Human Genetics and Molecular Biology
(Mahalaxmi Iyer) - Avinashilingam Institute for Home Science and Higher Education for Women Department of Zoology
(Subramaniam Mohana Devi) - Vision Research Foundation Department of Genetics and Molecular Biology
(Raj Neethu) - Bharathiar University Department of Human Genetics and Molecular Biology
(Dayem Ahmed Abdal) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
ÀÓ°æ¹Î(Lim Kyung-Min) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
±è¼¼Á¾(Kim Se-Jong) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
¾ÈÁ¾¿±(An Jong-Yub) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
ÀÌÀ±ÁÖ(Lee Yoon-Joo) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
ÃÖÀ¯Áø(Choi Yu-Jin) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
(Kirubhakaran Arthi) - Bharathiar University Department of Human Genetics and Molecular Biology
Á¶½Ö±¸(Cho Ssang-Goo) - Konkuk University Department of Stem Cell and Regenerative Biotechnology
(Vellingiri Balachandar) - Bharathiar University Department of Human Genetics and Molecular Biology
Abstract
The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials forCOVID-19.
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COVID-19, Exosome, Immunomodulation, Mesenchymal stem cells (MSCs), Ongoing Clinical trials, Therapy
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In this review, authors discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19.