´ëÀå¾Ï ȯÀÚ¿¡¼ º¹¸· ÀüÀÌ¿¡ ´ëÇÑ º¹¼ö³» ¾ÏÅÂ¾Æ Ç׿ø(Carcinoembryonic Antigen)ÀÇ Áø´ÜÀû °¡Ä¡
Diagnostic Value of Carcinoembryonic Antigen in Ascites for Colorectal Cancer with Peritoneal Carcinomatosis
´ëÇѼÒȱâÇÐȸÁö 2018³â 71±Ç 6È£ p.332 ~ p.337
¼Û¼ºÀº(Song Sung-Eun) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÃÖ¹Ù¿ï(Choi Pa-Ul) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
±èÀçÇö(Kim Jae-Hyun) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Á¤°æ¿ø(Jung Kyoung-Won) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
±è¼ºÀº(Kim Sung-Eun) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹®¿ø(Moon Won) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹Ú¹«ÀÎ(Park Moo-In) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹Ú¼±ÀÚ(Park Seon-Ja) - °í½Å´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Abstract
Background/Aims: Diagnostic tests for carcinoembryonic antigen (CEA) in ascites have been performed in various malignant cases, but there is only few data on the applicability of CEA for colorectal cancer (CRC) patients with peritoneal carcinomatosis. We aimed to determine the usefulness of CEA in ascites (aCEA) as a diagnostic parameter for CRC with peritoneal carcinomatosis.
Methods: Between January 2000 and May 2013, the medical records of 259 patients who underwent paracentesis for the evaluation of ascites were retrospectively reviewed. CRC patients with ascites (n=82) and patients with non-malignant ascites (n=177) were evaluated. Patients who had other malignancies, including gastric or ovarian cancer, with ascites were excluded. The optimal diagnostic cut-off value of aCEA for CRC with peritoneal carcinomatosis was determined using receiver operating characteristic curve analysis. The value of aCEA for predicting the occurrence of peritoneal carcinomatosis was evaluated using a logistic regression model.
Results: The optimal cut-off value of aCEA to diagnose CRC with peritoneal carcinomatosis was 3.89 ng/mL, and the area under the curve for aCEA was 0.996 (sensitivity 96.3%, specificity 100%, positive predictive value 100%, negative predictive value 98.3%). Multivariate logistic regression analysis showed that aCEA was an independent factor predicting the occurrence of peritoneal carcinomatosis.
Conclusions: In this study, we showed that aCEA may be a useful parameter for diagnosing CRC with peritoneal carcinomatosis, and we propose an optimal aCEA cut-off value of 3.89 ng/mL. Further study that includes patients with other malignant ascites may be necessary to validate these findings.
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Carcinoembryonic antigen, Ascites, Peritoneal neoplasms, Colorectal neoplasms
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À¯È¿¼º°á°ú(Recomendation)
This study showed that aCEA may be a useful parameter for diagnosing CRC with peritoneal carcinomatosis.