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Effects of Garlic Shoot Extract on Lipid Metabolism in Hyperlipidemic Rats Fed a High-fat Diet
Journal of Life Science 2015³â 25±Ç 3È£ p.276 ~ p.284
ȲÃÊ·Õ(Hwang Cho-Rong) - (Àç)³²Çظ¶´Ã¿¬±¸¼Ò
°Àç¶õ(Kang-Jae-Ran) - (Àç)³²Çظ¶´Ã¿¬±¸¼Ò
°¹ÎÁ¤(Kang Min-Jung) - (Àç)³²Çظ¶´Ã¿¬±¸¼Ò
½ÉÇýÁø(Sim Hye-Jin) - (Àç)³²Çظ¶´Ã¿¬±¸¼Ò
½ÅÁ¤Çý(Shin Jung-Hye) - (Àç)³²Çظ¶´Ã¿¬±¸¼Ò
Abstract
°íÁö¹æ½ÄÀÌ·Î À¯µµµÈ °íÁöÇ÷Áõ ÈòÁã¿¡ ¸¶´ÃÁ¾ 50% ¹× 75% ¿¡Åº¿Ã ÃßÃâ¹°À» °¢°¢ 200 ¹× 400 mg/kg B.W./day ³óµµ·Î Åõ¿©ÇÏ¿© Ç÷Áß ¹× °£ Á¶Á÷ÀÇ ÁöÁú ÇÔ·® º¯È¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» ºñ±³ÇÏ¿´´Ù. Ç÷û ÃÑ ÁöÁú ¹× Áß¼ºÁö¹æ ÇÔ·®Àº GSB-2±º¿¡¼ °¡Àå ³·¾Ò°í, ÃÑ ÄÝ·¹½ºÅ×·Ñ ÇÔ·®Àº GSA-2¿Í GSB-2±ºÀÌ ´ëÁ¶±º¿¡ ºñÇØ À¯ÀÇÀûÀ¸·Î ³·¾Ò´Ù. HDL-ÄÝ·¹½ºÅ×·Ñ ÇÔ·®Àº ½ÇÇ豺 Áß GSB-2±ºÀÌ Á¤»ó±º°ú À¯»çÇÑ ¼öÁØÀ» º¸¿´°í, LDL- ¹× VLDL-ÄÝ·¹½ºÅ×·Ñ ÇÔ·®Àº GSB-1±º ¹× GSB-2±ºÀÌ ´ëÁ¶±º¿¡ ºñÇØ À¯ÀÇÀûÀ¸·Î ³·¾Ò´Ù. AI ¹× CRF Áö¼ö´Â GSB-2±º¿¡¼ °¢°¢ 0.58 ¹× 1.57·Î °¡Àå ³·Àº ¼öÁØÀ̾ú´Ù. Ç÷û AST, ALT ¹× ALP È°¼ºÀº GSA-2 ¹× GSB-2±º¿¡¼ ´ëÁ¶±º¿¡ ºñÇØ À¯ÀÇÀûÀ¸·Î ³·¾Ò´Ù. °£ Á¶Á÷ Áß ÃÑ ÁöÁú ÇÔ·®Àº ¸ðµç ½ÇÇ豺ÀÌ ´ëÁ¶±º¿¡ ºñÇØ ³·Àº ÇÔ·®À̾úÀ¸³ª ½ÇÇ豺°£¿¡ À¯ÀÇÂ÷´Â ¾ø¾ú´Ù. °£ Á¶Á÷ Áß ÃÑ ÄÝ·¹½ºÅ×·Ñ ¹× Áß¼ºÁö¹æ ÇÔ·®Àº GSB-2±º¿¡¼ °¡Àå ³·¾Ò´Ù. Ç÷û ¹× °£ Á¶Á÷ÀÇ Ç×»êÈ È°¼ºÀº GSB-2±º¿¡¼ °¢°¢ 40.16% ¹× 47.41%·Î °¡Àå ³ô¾Ò´Ù. Ç÷û ¹× °£ Á¶Á÷ÀÇ ÁöÁú°ú»êȹ° ÇÔ·®Àº ½ÇÇ豺 Áß GSB-2±º¿¡¼ °¡Àå ³·¾Ò´Ù.
This study was designed to investigate the effect of garlic shoot extract administration on serum and liver tissue lipid levels in hyperlipidemic rats. The rats were fed a 45% high-fat diet to induce hyperlipidemia. They were then administered garlic shoot extract (50%) and ethanol extract (75%) at 200 mg/kg B.W./day (GSA-1, GSB-1) and 400 mg/kg B.W./day (GSA-2, GSB-2) for 5 weeks. The total lipid and triglyceride contents in serum were lowest in the GSB-2 group, and the total cholesterol content was significantly lower in the GSA-2 and GSB-2 groups than in the control group. The high density lipoprotein (HDL)-cholesterol content of the GSB-2 group was similar to that of the normal group. The low density lipoprotein (LDL) and very low density lipoprotein (VLDL)-cholesterol contents were significantly lower in the GSB-1 and GSB-2 group than in the control group. atherogenic index (AI) and cardiac risk factor (CRF) were lowest in the GSB-2 group (0.58 and 1.57, respectively). Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities were significantly higher in the control group than in the normal group, and the levels of AST, ALT, and ALP were significantly lower in the GSA-2 and GSB-2 groups than in the control group. The total lipid content in liver tissue was significantly lower in all the experimental groups compared to that of the control group, but it was not significantly different among the experimental groups. The total cholesterol and triglyceride content in liver tissue was lowest in the GSB-2 group. Antioxidant activity in serum and liver tissue was highest in the GSB-2 group (40.16% and 47.41%, respectively).The thiobarbituric acid reactive substance (TBARS) content in serum and liver tissue was lowest in the GSB-2 group, with the significant difference. Our results suggest that garlic shoot extracts may improve lipid metabolism in serum and liver tissue and potentially reduce hyperlipidemia.
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Garlic shoot extract, high fat diet, hypolipidemia, lipid metabolism
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