Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis
Yonsei Medical Journal 2020³â 61±Ç 10È£ p.891 ~ p.894
¹ÚÁöÇý(Park Ji-Hye) - Yonsei University College of Medicine Department of Internal Medicine
Á¤´ÙÀº(Jeong Da-Eun) - Yonsei University College of Medicine Severance Biomedical Science Institute
Á¤¿¬¿í(Chung Youn-Wook) - Yonsei University College of Medicine Severance Biomedical Science Institute
±è´ÙÇý(Kim Da-Hye) - Yonsei University College of Medicine Severance Biomedical Science Institute
õÀçÈñ(Cheon Jae-Hee) - Yonsei University College of Medicine Department of Internal Medicine
·ùÁöȯ(Ryu Ji-Hwan) - Yonsei University College of Medicine Severance Biomedical Science Institute
Abstract
The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Beh?et's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.
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Coronavirus, SARS-CoV-2, COVID-19, angiotensin converting enzyme 2, proteomics
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This article reported that gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.