Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study
Yonsei Medical Journal 2020³â 61±Ç 5È£ p.431 ~ p.437
È«°æ¼ö(Hong Kyung-Soo) - Yeungnam University College of Medicine Department of Internal Medicine
ÀÌ°üÈ£(Lee Kwan-Ho) - Yeungnam University College of Medicine Department of Internal Medicine
Á¤ÁøÈ«(Chung Jin-Hong) - Yeungnam University College of Medicine Department of Internal Medicine
½Å°æö(Shin Kyeong-Cheol) - Yeungnam University College of Medicine Department of Internal Medicine
ÃÖÀº¿µ(Choi Eun-Young) - Yeungnam University College of Medicine Department of Internal Medicine
ÁøÇöÁ¤(Jin Hyun-Jung) - Yeungnam University College of Medicine Department of Internal Medicine
ÀåÁ¾°É(Jang Jong-Geol) - Yeungnam University College of Medicine Department of Internal Medicine
ÀÌ¿øÈ(Lee Won-Hwa) - Korea Research Institute of Bioscience and Biotechnology Aging Research Center
¾ÈÁØÈ«(Ahn June-Hong) - Yeungnam University College of Medicine Department of Internal Medicine
Abstract
Although some information on the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a few selected cases has been reported, data on the clinical characteristics and outcomes of patients hospitalized therewith in South Korea are lacking. We conducted a retrospective single-center study of 98 consecutive hospitalized patients with confirmed SARS-CoV-2 infection at Yeungnam University Medical Center in Daegu, South Korea. Sixty patients were women (61.2%), and the mean age was 55.4¡¾17.1 years. Thirteen patients (13.3%) were treated in the intensive care unit (ICU). The mean interval from symptom onset to hospitalization was 7.7¡¾4.5 days. Patients who received ICU care were significantly older and were more likely to have diabetes mellitus. The National Early Warning Score on the day of admission was significantly higher in patients requiring ICU care. Acute respiratory distress syndrome (13/13 patients; 100%), septic shock (9/13; 69.2%), acute cardiac injury (9/13; 69.2%), and acute kidney injury (8/13; 61.5%) were more common in patients who received ICU care. All patients received antibiotic therapy, and most (97/98 patients; 99.0%) received antiviral therapy (lopinavir/ritonavir). Hydroxychloroquine was used in 79 patients (80.6%), and glucocorticoid therapy was used in 18 patients (18.4%). In complete blood counts, lymphopenia was the most common finding (40/98 patients; 40.8%). Levels of all proinflammatory cytokines were significantly higher in ICU patients. As of March 29, 2020, the mortality rate was 5.1%. Here, we report the clinical characteristics and laboratory findings of SARS-CoV-2 patients in South Korea up to March 29, 2020.
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Coronavirus, SARS-CoV-2, COVID-19, Korea, clinical characteristics
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The National Early Warning Score on the day of admission was significantly higher in patients requiring ICU care. Acute respiratory distress syndrome (13/13 patients; 100%), septic shock (9/13; 69.2%), acute cardiac injury (9/13; 69.2%), and acute kidney injury (8/13; 61.5%) were more common in patients who received ICU care; In complete blood counts, lymphopenia was the most common finding (40/98 patients; 40.8%). Levels of all proinflammatory cytokines were significantly higher in ICU patients.