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Clinical Evaluation of Human Papillomavirus DNA Genotyping Assay to Diagnose Women Cervical Cancer

대한의생명과학회지
2012년 18권 2호 p.123 ~ p.130
 ( Kim Sung-Hyun ) - Yonsei University College of Health Science Department of Biomedical Laboratory Science

 ( Lee Dong-Sup ) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
 ( Kim Ye-un ) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
 ( Kim Gee-Hyuk ) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
 ( Park Sang-Jung ) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
 ( Choi Yeon-Im ) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
 ( Kim Tae-Ue ) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
 ( Park Kwang-Hwa ) - Yonsei University Wonju College of Medicine Department of Pathology
 ( Lee Hye-Young ) - Yonsei University College of Health Science Department of Biomedical Laboratory Science

Abstract

In this study, we evaluated the human papillomavirus (HPV) genotyping test called MolecuTech REBA HPV-ID® (YD Diagnostics, Seoul, Korea) for 704 women who also had cervical cytological evaluations by Thin Prep. The infection rate of high-risk HPV genotypes was 56.6% in patients with normal cytology, 59.8% in those with benign, low-grade squamous intraepithelial lesions, 51.4% in those with atypical squamous cells of uncertain significance, 92.3% in those with high-grade squamous intraepithelial lesions, and 94.1% in those with squamous cell carcinoma or adenocarcinoma. HPV 16 was the most common genotype detected in any lesion, followed by HPV 53, 58, 33, 52, 45, 31, and 35, in order. The HPV DNA test with PCR-REBA is a very highly sensitive, but less specific, method. The infection rates and HPV genotype distribution of non-Korean people versus people from South Korea showed regional differences.

키워드

원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) 
주제코드
주제명
(Target field)
연구대상
(Population)
연구참여
(Sample size)
대상성별
(Gender)
질병특성
(Condition Category)
연구환경
(Setting)
연구설계
(Study Design)
연구기간
(Period)
중재방법
(Intervention Type)
중재명칭
(Intervention Name)
키워드
(Keyword)
유효성결과
(Recomendation)
연구비지원
(Fund Source)
근거수준평가
(Evidence Hierarchy)
출판년도
(Year)
참여저자수
(Authors)
대표저자
(1st Authors)
Doi
KCD코드
ICD 03
건강보험코드